منابع مشابه
Development of Efflux Pumps and Inhibitors (EPIs) in A. baumanii
Acinetobacter baumanii is a Gram-negative, non-fermenting, oxidase-negative and non-motile coccobacillus, [1]. It can survive in water, soil, surface of skin and hospital environment. It cause a series of opportunistic infections such as epidemic pneumonia, skin and soft tissue infections, bacteraemia, urinary tract infections and septicemia app:addword:septicemia in immunocompromised patients,...
متن کاملCurrent Advances in Developing Inhibitors of Bacterial Multidrug Efflux Pumps
Antimicrobial resistance represents a significant challenge to future healthcare provision. An acronym ESKAPEE has been derived from the names of the organisms recognised as the major threats although there are a number of other organisms, notably Neisseria gonorrhoeae, that have become equally challenging to treat in the clinic. These pathogens are characterised by the ability to rapidly devel...
متن کاملInhibitors of bacterial multidrug efflux pumps potentiate antimicrobial photoinactivation.
Antimicrobial photodynamic inactivation (APDI) combines a nontoxic photoactivatable dye or photosensitizer (PS) with harmless visible light to generate singlet oxygen and reactive oxygen species that kill microbial cells. Cationic phenothiazinium dyes, such as toluidine blue O (TBO), are the only PS used clinically for APDI, and we recently reported that this class of PS are substrates of multi...
متن کاملBacterial Efflux Pumps
Bacteria and cancer cells develop resistance to more than one agent as a consequence of being exposed to ineffective levels of the agent for a prolonged period of time. The resistance of these cells is mediated by over-expressed efflux pumps that have the ability to extrude a large variety of unrelated chemicals. This review discusses the main types of multidrug resistant (MDR) efflux systems o...
متن کاملAntibiotic efflux pumps.
Active efflux from procaryotic as well as eucaryotic cells strongly modulates the activity of a large number of antibiotics. Effective antibiotic transport has now been observed for many classes of drug efflux pumps. Thus, within the group of primary active transporters, predominant in eucaryotes, six families belonging to the ATP-binding cassette superfamily, and including the P-glycoprotein i...
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ژورنال
عنوان ژورنال: VNU Journal of Science: Medical and Pharmaceutical Sciences
سال: 2019
ISSN: 2588-1132,2615-9309
DOI: 10.25073/2588-1132/vnumps.4188